Thalidomide-A novel therapeutic approach for pruritic papular eruption of HIV.
نویسندگان
چکیده
HIV: Human immunodeficiency virus PPE: Pruritic papular eruption of HIV ART: Anti-retroviral therapy DLQI: Dermatology life quality index VAS: Visual analogue scale INTRODUCTION Pruritic papular eruption of HIV (PPE) represents an intensely pruritic papular rash with greatest severity on the extensor surfaces of extremities. It is one of the most common cutaneous manifestations in HIV-infected individuals, in whom prevalence ranges between 11% and 46% depending on geographic location. Persistent or recurrent PPE despite effective antiretroviral therapy (ART) may be associated with higher viral load at ART initiation. Although pathogenesis is uncertain, an exaggerated immunologic reaction to arthropod bites has been suggested because of geographical restriction to the tropics, localization to the extremities, similarity in histology, and increased peripheral eosinophil counts. The optimum treatment pathway is poorly defined because of lack of evidence for different treatment modalities. We report a case of recurrent PPE responding well to oral thalidomide during a 3-month treatment period.
منابع مشابه
Factors associated with pruritic papular eruption of human immunodeficiency virus infection in the antiretroviral therapy era.
BACKGROUND Pruritic papular eruption (PPE) of HIV is common in HIV-infected populations living in the tropics. Its aetiology has been attributed to insect bite reactions and it is reported to improve with antiretroviral therapy (ART). Its presence after at least 6 months of ART has been proposed as one of several markers of treatment failure. OBJECTIVES To determine factors associated with PP...
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عنوان ژورنال:
- JAAD case reports
دوره 1 3 شماره
صفحات -
تاریخ انتشار 2015